Adding a certain compound to certain chemical reactions, such as: 70484-02-5, name is 6-Bromonaphthalene-2,3-dicarbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 70484-02-5, COA of Formula: C12H5BrN2
A mixture of 6-Bromodicyanonaphthalene(3) (1.0 g, 3.9 mmol), methyl-p-hydroxybenzoate (4)(2.0g, 13.2 mmol) and 6 g of K2CO3 in dry DMF (60 mL) was heated at 130for 20 h. After cooling down, the mixture was poured into ice water and extracted with chloroform, and then was washed with water thoroughly. The organic phase was dried over anhydrous MgSO4and concentrated, which was chromatographed (silica gel) usingCHCl3/ethyl acetate (40:1) as the eluent to give 5 as a white solid (0.28 g, 22%). 1H NMR (300 MHz, CDCl3, 25C, TMS): (ppm): 3.94 (s, 3H, CH3), 7.14 (d, 2H, Ar-H, J = 8.7), 7.38 (d, 1H, Ar-H, J=2.4 Hz), 7.56 (dd, 1H, Ar-H, J1=2.4 Hz, J2=9.0 Hz), 8.0 (d, 1H,Ar-H, J=9.0 Hz),8.12 (d, 2H, Ar-H, J=8.7 Hz), 8.18 (s, 1H, Ar-H), 8.33 (s, 1H, Ar-H). 13C NMR(75MHz, CDCl3, 25C, TMS): (ppm): 52.25, 108.96, 111.14, 114.03, 115.69, 115.84, 119.39, 124.29, 126.87, 129.80, 131.09, 132.14, 134.67, 134.75, 135.57, 158.54, 159.15, 166.17. MS (ESI) m/z 329.09; (M+H+) (calculated for 329.32).
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Reference:
Article; Luan, Liqiang; Ding, Lanlan; Zhang, Weijia; Shi, Jiawei; Yu, Xiaoqiang; Liu, Wei; Bioorganic and Medicinal Chemistry Letters; vol. 23; 13; (2013); p. 3775 – 3779;,
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