Synthetic Route of 3100-67-2, A common heterocyclic compound, 3100-67-2, name is 1-Amino-2-naphthonitrile, molecular formula is C11H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The dried 1 L reactor was charged with nitrogen and then 50.0 g (297 mmol) of intermediate 13-a,500 mL of dimethylformamide is stirred.55.56 g (312 mmol) of N-bromosuccinimide are slowly added to the reactor.Stir at room temperature for 4 hours.When the reaction was completed, distilled water was added dropwise at room temperature to precipitate brown crystals. The crystals were separated by filtration and separated by column chromatography to obtain 68 g of intermediate 13-b.(Yield: 93%)
The synthetic route of 3100-67-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SFC Ltd.; Choi Yeong-tae; Lee Se-jin; Park Seok-bae; Ryu Tae-jeong; Yang Byeong-seon; Lee Da-jeong; (92 pag.)KR2018/10087; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts