Adding a certain compound to certain chemical reactions, such as: 590-17-0, name is 2-Bromoacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 590-17-0, category: nitriles-buliding-blocks
Screening of A3a in existing CWR protocols – standard room temperature conditions: Scheme A52. Screening of A3a in RT-CWR conditions.Benzaldehyde (100 iL, 1.0 mmol, 1.0 equiv.), bromoacetonitrile (86 iL, 1.3 mmol, 1.3 equiv.), phenylsilane (172 iL, 1.3 mmol, 1.3 equiv.) and DIPEA (244 pL, 1.4 mmol, 1.4 equiv.) were reacted using A3a (23 mg, 0.1 mmol, 10 mol %) and 4-nitrobenzoic acid (17 mg, 0.1 mmol, 10 mol %) in ethyl acetate (0.33 mL) at RTfor24 h (Scheme S2). The crude product was analyzed by 1H NMR spectroscopy, which showed 100%conversion to product and an E/Z ratio of 93:7.The crude product was purified via flash column chromatography to afford pure product as a colorless oil (126 mg, 98%, E/Z93:7).
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Reference:
Patent; DUBLIN CITY UNIVERSITY; O’BRIEN, Christopher; WO2014/140353; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts