6136-68-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6136-68-1 name is 3-Acetylbenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Potassium tert-butoxide (4.5 g, 40.10mmol) was taken in dry diethyl ether (200ml)at room temperature under N2 atmosphere at stirring condition. Diethyl oxalate (4.4 ml, 30.10mmol) was added to that solution. After 15 min of stirring, 3-acetylbenzonitrile (4.35 g, 29.96 mmol) was added to the resulting mixtureand the stirring was continuing for overnight.A light yellow precipitate was obtained and the whole resulting mixture is taken in a separating funnel. This solution was washed three times with 20 ml of water. The entire aqueous layer was collected in a beaker, cooled for some time and then dilute HCl (2 ml) was added to it dropwise until the whole solution became just acidic. A yellow precipitate was obtained which was filtered and product ethyl 4-(3-cyanophenyl)-2,4-dioxobutanoatewas isolated as a yellow solid (3.3 g, 76.74 yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Acetylbenzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Roy, Manasi; Adhikary, Amit; Debnath, Tanay; Das, Abhijit Kumar; Mondal, Raju; Polyhedron; vol. 160; (2019); p. 46 – 52;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts