In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 939-80-0, name is 4-Chloro-3-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 939-80-0
In a flask equipped with a reflux condenser, frans-4-aminocyclohexanol hydrochloride(2.70g, 17.80mmoles) was suspended in iso-propanol (15m1). To this stirred suspension,triethylamine (4,40m1, 31 .49mmoles) was slowly added, followed by 4-chloro-3- nitrobenzonitrile (2.50g, 13.69mmoles). The resulting yellow suspension was heated at 65C for 36h, allowed to cool down to room temperature before water (lOml) was added to the reaction mixture. The resulting precipitate was collected by filtration andsuccessively washed with water and iso-propanol, to yield 4-(((1R,4R)-4- hydroxycyclohexyl)amino)-3-nitrobenzonitrile as a yellow crystalline solid (3 .28g, 12.55mmoles, 92%). The resulting solid was further purified by recrystallization from hot ethanol.mlz 262.2 [MJ-1]+?H NMR (500 MHz, DMSO-d6) oe 8.49 (s, 1H), 8.18 (d, J = 7.8 Hz, 1H), 7.79 (d, J = 9.0 Hz, 1H), 7.26 (d, J = 9.1 Hz, 1H), 4.63 (s, 1H), 3.67 (dtd, J = 14.9, 10.4, 4.0 Hz, 1H), 3.57-3.41 (m, 1H), 2.05-1.88 (m, 2H), 1.89-1.75 (m,2H), 1.53-1.19 (m, 4H).
The synthetic route of 939-80-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RE:VIRAL LTD; COCKERILL, Stuart; MATHEWS, Neil; WARD, Simon; LUNN, Graham; PARADOWSKI, Michael; GASCON SIMORTE, Jose Miguel; (72 pag.)WO2016/55780; (2016); A1;,
Nitrile – Wikipedia,
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