Synthetic Route of 1220630-83-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1220630-83-0 name is 3-Amino-4-(trifluoromethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(b) tert-Butyl N-[5-cyano-2-(trifluoromethyl)phenyl1-carbamateA mixture of 3-amino-4-(trifluoromethyl)benzonitrile (10.0 g; 53.7 mmol), DCM (100 ml.) and TEA (8.2 ml 59 mmol) was treated dropwise with a solution of BOC2O (12.9 g; 59.1 mmol) in DCM (50 ml.) at 00C and thereafter stirred over night. Another portion of BoC2O in DCM and DMAP (656 mg; 5.37 mmol) was added and the mixture was stirred for another 12 h at rt, washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography to give the sub-title compound. Yield: 8.50 g (55%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-4-(trifluoromethyl)benzonitrile, and friends who are interested can also refer to it.