Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108168-88-3, name is N-(tert-Butyl)-2-cyanoacetamide, A new synthetic method of this compound is introduced below., Safety of N-(tert-Butyl)-2-cyanoacetamide
To a 10 ml sealed tube, N-((2S,3R)- l-(((S)-l-((2-fluoro-4-methylbenzyl)amino)-3-(3- formylphenoxy)-l – oxopropan -2-yl)amino)-3-hydroxy-l -oxobutan-2-yl)-5-methylisoxazole-3- carboxamide (1 10 mg, 0.2 mmol) and N-(tert-butyl)-2-cyanoacetamide (85.5 mg, 0.61 mmol) were dissolved in methanol (2 ml). Piperidine (2 drops) was added to the reaction mixture and stirred at 80 C for 1 h. Water was added and the product was extracted with ethyl acetate, the combined organic later was dried over sodium sulfate, filtered and concentrated. The crude material was purified using flash chromatography and further triturated with diethyl ether to yield 30 mg of the title compound. LC-MS (ES, m/z): 663 [M+H
The synthetic route of 108168-88-3 has been constantly updated, and we look forward to future research findings.