Related Products of 868-54-2, A common heterocyclic compound, 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, molecular formula is C6H4N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Triethylamine (0.3 mmol) was added with stirring to an emulsion of salicylaldehyde 1 (3 mmol), 2-aminoprop-1-ene-1,1,3-tricarbonitrile (3 mmol, 0.40 g), and 2-pyrazolin-5-one 2 (3 mmol) in propanol or acetonitrile (2 mL). Then the mixture was stirred under reflux for 1 h, cooled, transferred onto a filter, washed with methanol (2 × 3 mL), and dried to isolate pure compound 3. In some cases, additional crystallization from DMSO was required.
The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.