Electric Literature of 21524-39-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21524-39-0, name is 2,3-Difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2, 3-difluorobenzonitrile (19. 0 g, 137 mmol) and ethanol (200 ml) pre-saturated with ammonia gas was heated at 140C in an autoclave for 8 h (terminal pressure 200 psi). The mixture was allowed to cool to ambient temperature and evaporated to dryness. The residue was dissolved in water (400 ml) and extracted with diethyl ether (2 x 300 ml). The combined organics were washed with water (300 ml) and brine (250 ml), dried over anhydrous magnesium sulfate, filtered and evaporated. Trituration with isohexane (150 ml) afforded 2-amino-3-fluorobenzonitrile (9.8 g, 50%) as an off-white solid: 1H NMR (360 MHz, CDCl3) 8 4.47 (2H, s), 6.65-6. 71 (1H, m), 7.14-7. 20 (2H, m).
The synthetic route of 2,3-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.