21524-39-0, name is 2,3-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks
To a solution of 51-(pynOlidm-1-ylsulfonyl)spirofl ,3-dioxane-2,3′-indol]-2′(r//)-one (400 mg, 1.2 mmol) in DMF (12 mL) was added 60% NaH (60 mg, 1 5 mmol). After stir?ng for 10 minutes at room temperature, a 3.0 mL aliquot of this solution (0.3 mmol) was added to 2,3-difluorobenzonit?le (83 mg, 0.6 mmol) in DMF (2 mL), The resulting solution was stirred at 60 C for 12 hours. The reepsilonction was diluted with EtOAc, washed with H;O and brme, then dried (MgSO4), filtered, and concentrated. The crude residue was purified by flash chromatography on silica gel (30 1 CH2CI1/ EtOAc) to provide 87 mg (630O) of the title compound as a white solid. 1H NMR (400 MHz, CDCl3) consistent, MS (ES) m,z 458.1 (M-H)
The synthetic route of 21524-39-0 has been constantly updated, and we look forward to future research findings.