Synthetic Route of 50594-78-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50594-78-0, name is 5-Fluoro-2-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Step 1 : 6-(N-(3-cyano-4-nitrophenyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N- methylbenzofuran-3-carboxamide A mixture of 5-fluoro-2-nitrobenzonitrile (1 .280 mL, 1 1 .18 mmol), 5-cyclopropyl-2-(4- fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide (3.0 g, 7.45 mmol) and K2CO3 (3.09 g, 22.36 mmol) in 1 ,2-dimethoxyethane (30 mL) and water (7.5 mL) in a seal tube was heated to 80 0 C overnight. It was cooled down to room temperature, diluted with EtOAc, filtered and the off-white solid was washed with water and then dried in vacuo to give crude desired product as a yellow solid (80 % purity, 3.9 g, 76 %). LCMS {m/z, ES+) = 549 (M+H+)
The chemical industry reduces the impact on the environment during synthesis 5-Fluoro-2-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.