Adding a certain compound to certain chemical reactions, such as: 330793-38-9, name is 4-Bromo-2-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 330793-38-9, Application In Synthesis of 4-Bromo-2-methoxybenzonitrile
2-(6-(5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidin-4-yl)amino)pyridin-3-yl)propan-2-ol (20 mg) obtained in ReferenceExample 4, 4-bromo-2-methoxybenzonitrile (22 mg), tris(dibenzylideneacetone)dipalladium (6.4 mg), Xantphos(8.1 mg), and sodium tert-butoxide (10 mg) were suspended in dioxane (0.4 mL), followed by stirring under microwaveirradiation at 130°C for 40 minutes. Insolubles were removed from the reaction mixture by filtration, and the resultingsolution was purified by reversed-phase preparative HPLC column chromatography. The resulting fraction was concentratedunder reduced pressure to obtain the target compound.
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