Extended knowledge of 3-Fluorobenzonitrile

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H4FN

Example 19.1 : 3-Fluoro-N-hydroxy-benzamidine3-Fluorobenzonitrile (2.5 g, 0.021 mol), diisopropylethyl amine (10.8 mL, 0.062 mol) and hydroxylamine hydrochloride (4.3 g, 0.062 mol) were mixed in ethanol (30 mL). The reaction mixture was stirred at 70 0C overnight. The reaction mixture was cooled to room temperature and concentrated to half the original volume. The residue was added to a mixture of dichloromethane (200 mL) and water (60 mL). The mixture was basified to pH 9 using 2N NaOH and the organic phase was separated. The aqueous phase was extracted further with dichloromethane (2 x 50 mL) and the combined organic phase was washed with water (75 mL), washed with brine (75 mL), dried over sodium sulfate and concentrated to give the product as a yellow solid (2.8 g, 89 %). 1H NMR (300 MHz, CDCI3): delta 8.05 (bs, 1 H), 7.39 (m, 3H), 7.16 (m, 1 H), 4.88 (bs, 2H).

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.