A common heterocyclic compound, 151-18-8, name is 3-Aminopropanenitrile, molecular formula is C3H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 151-18-8.
EXAMPLE 2 To 59.5 parts of sodium methylate is added 300 parts by volume of tetrahydrofuran, and the mixture is cooled at -5C and then to the mixture is added dropwise 70 parts of beta-aminopropionitrile. Into the mixture is introduced carbon monoxide at 50 kg/cm2 G at 70C for 4 hours to allow the reaction to take place. After completion of the reaction, the solvent is removed and the crystals are recovered by filtration and washed with tetrahydrofuran, whereby 116 parts of alpha-sodioformylbeta-formylaminopropionitrile is obtained. Melting point: 178C(decomp.) Purity: 79 %. Yield: 62 %.
The synthetic route of 3-Aminopropanenitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US3954756; (1976); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts