Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64695-82-5, name is 2-Bromo-4,5-difluorobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 64695-82-5
0362] A solution of 2-bromo-4,5-difluorobenzonitrile (218 mg, 1.00 mmol), D-leucine amide hydrochloride (185 mg, 1.10 mmol) and DIEA (0.600 mL, 3.45 mmol) in DMSO (3 mL) was stirred at 120 C for 18 h. Water and EtOAc were added. The organic phase was separated, washed with water, dried over Na2S04, concentrated in vacuo. The residue was purified by a silica gel column, eluted with 0-50% EtOAc in hexane to give (R)-2-(5-bromo- 4-cyano-2-fluorophenylamino)-4-methylpentanamide (175 mg).
The synthetic route of 64695-82-5 has been constantly updated, and we look forward to future research findings.