42872-74-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 42872-74-2 as follows.
Intermediate 28a) A solution of 3-bromo-4-methylbenzonitrile (1 g), acetamidine hydrochloride (714 mg), cesium carbonate (5 g) and copper (I) bromide (36 mg) in dry dimethyl sulfoxide (25 mL) was stirred at 120 C for 3 h. The mixture was chilled, diluted with EtOAc (200 mL) and washed with water. The organic layer was dried and the volatiles were removed under reduced pressure. The residue was purified by chromatography (Si02, 150 g, DCM/ MeOH) to yield the desired product (36% yield). LC-MS (Method 1): m/z [M+H]+ = 252.1 (MW calc. = 252.11 ); R, = 3.5 min.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 42872-74-2, and friends who are interested can also refer to it.
Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; WACHTEN, Sebastien; KLESS, Achim; VOSS, Felix; RITTER, Stefanie; WO2014/108337; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts