In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: nitriles-buliding-blocks
According to the method described in Embodiment 1,Add 1d (0.5mmol, 88mg) and 2f (1.25mmol) to a 15mL pressure tube.190mg),Dichloro (pentamethylcyclopentadienyl yl)rhodium (III) dimer (0.025mmol, 15mg), copper acetate monohydrate (1mmol, 200mg),Cesium acetate (0.25mmol, 48mg) and 1,2-dichloroethane (2 mL), under an air atmosphere and the reaction tube was sealed, and then placed in an oil bath at 80 reaction was stirred 14h. The reaction was quenched with 10mL of water was added, extracted with ethyl acetate (10mL ¡Á 3), then the organic phase was washed with water and saturated brine successively, dried over anhydrous sodium sulfate. Filtration, rotary evaporation, separating silica gel column (petroleum ether / ethyl acetate = 5/1) to give a yellow solid 3df (136mg, 70%).
The synthetic route of 3672-47-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Henan Normal University; Fan Xuesen; Guo Chenhao; Zhang Beibei; Zhang Xinying; Li Bin; (17 pag.)CN108997298; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts