Adding a certain compound to certain chemical reactions, such as: 326-62-5, name is 2-(2-Fluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 326-62-5, Computed Properties of C8H6FN
General procedure: To a solution of 9 (20 mmol) in anhydrous DMF (100 mL) was added appropriate aryl acetonitriles (22 mmol) at room temperature. After the mixture was stirred for 0.5 h, 60% NaH (1.0 g, 24 mmol) was added portion wise at -10C under a nitrogen atmosphere. The whole mixture was stirred at the same temperature for 1 h, warmed to room temperature and then reacted for 48-72 h. The resulting mixture was acidified with acetic acid under ice cooling and concentrated under reduced pressure to afford the crude intermediate 10. Then, without further purification, EtOH (300 mL) was added at room temperature. After stirred for 0.5 h, 10% NaOH (100 mL) was added dropwise under ice cooling. The reaction mixture was then stirred at room temperature for 24-48 h and then acidified to pH 5-6 with acetic acid. After most of the solvent was removed under reduced pressure, the resulting residue was poured into water and extracted with CH2Cl2. The organic layer was dried over Na2SO4 and concentrated in vacuo to give the crude product, which was first purified by flash chromatography (eluent: CH2Cl2) and followed by recrystallization from MeOH or AcOEt, to afford target compounds 3a-h.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Fluorophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Chen, Guo-Shen; Du, Fen; Zhao, Tian-Sheng; Xiong, Yuan-Zhen; Indian Journal of Heterocyclic Chemistry; vol. 28; 2; (2018); p. 255 – 260;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts