105-34-0, A common heterocyclic compound, 105-34-0, name is Methyl 2-cyanoacetate, molecular formula is C4H5NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Benzaldehyde SI-10 (1.59 g, 15 mmol, 1.0 equiv) and methyl 2-cyanoacetate SI-6 (1.59 g, 16 mmol 1.1 equiv) were dissolved in 50 mL acetonitrile and polymer bound dimethyl benzylamine (QP-DMA, 10 g) were added. The whole mixture was stirred under N2 at 80 C for 18 h. The solvent was then removed under reduced pressure and the crude solid was recrystallised from ethanol to give 1.64 g ofwhite crystals. Isolated yield: 1.64 g (58%, 15 mmol)
The synthetic route of 105-34-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Mallia, Carl J.; Englert, Lukas; Walter, Gary C.; Baxendale, Ian R.; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 875 – 883;,
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