Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Yu, Shuling, once mentioned the application of 22445-42-7, Name is 3,5-Dimethylbenzonitrile, molecular formula is C9H9N, molecular weight is 131.17, MDL number is MFCD00060670, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category, Application In Synthesis of 3,5-Dimethylbenzonitrile.
Palladium-catalyzed tandem reaction of epoxynitriles with arylboronic acids in aqueous medium: divergent synthesis of furans and pyrroles
The efficient selective synthesis of furans and pyrroles has been realized by means of a palladium-catalyzed tandem addition/ring-opening/cyclization reaction of 2-(3-aryloxiran-2-yl)acetonitriles with arylboronic acids in aqueous medium for the first time. The chemoselectivity of this transformation can be predominantly governed by the steric effects of arylboronic acids: the reactions of 2-(3-aryloxiran-2-yl)acetonitriles with the less sterically hindered arylboronic acids provided furans as the sole products, while those of the sterically bulky arylboronic acids delivered pyrroles selectively. The O-18-labelled experiments revealed that the oxygen atom of furans is derived from water, and a plausible mechanism for this selective synthesis of furans and pyrroles was proposed.
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