Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of 2,6-Difluorobenzonitrile1897-52-5, Name is 2,6-Difluorobenzonitrile, SMILES is N#CC1=C(F)C=CC=C1F, belongs to nitriles-buliding-blocks compound. In a article, author is Murugesh, Nithya, introduce new discover of the category.
A Convenient Synthesis of Iguratimod-Amine Precursor via NHC-Catalyzed Aldehyde-Nitrile Cross Coupling Reaction
A protocol for the synthesis of iguratimod-amine precursor has been developed using N-heterocyclic carbene (NHC)-catalyzed aldehyde-nitrile cross coupling reaction with overall atom efficiency of 71 %. The first step involves a nucleophilic aromatic substitution (SNAr) of 1-chloro-4-methoxy-2-nitrobenzene (1) with phenol to produce 4-methoxy-2-nitro-1-phenoxybenzene (2) which further undergoes nitro reduction followed by mesylation to produce N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide (4). Furthermore, it was subjected to Vilsmeier-Haack formylation and demethylation (using BBr3) to produce N-(4-formyl-5-hydroxy-2-phenoxyphenyl)methanesulfonamide (6). Subsequently, O-alkylation followed by NHC-catalyzed aldehyde-nitrile cross coupling yields the amine precursor of iguratimod (8).
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1897-52-5. Quality Control of 2,6-Difluorobenzonitrile.