Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 622-75-3, Name is 2,2′-(1,4-Phenylene)diacetonitrile, molecular formula is C10H8N2, belongs to nitriles-buliding-blocks compound. In a document, author is Ye, Xuanzeng, introduce the new discover, Formula: C10H8N2.
Pd-Catalyzed Approach for Assembling 9-Arylacridines via a Cascade Tandem Reaction of 2-(Arylamino)benzonitrile with Arylboronic Acids in Water
A novel palladium-catalyzed protocol for the synthesis of 9-arylacridines via tandem reaction of 2-(arylamino)benzonitrile with arylboronic acids in water has been developed with good functional group tolerance. The present synthetic route could be readily scaled up to gram quantity without difficulty. This methodology was further extended to the synthesis of a 4′-OH derivative, which showed estrogenic biological activity. Preliminary mechanistic experiments showed that this transformation involves a nucleophilic addition of aryl palladium species to the nitrite to generate an aryl ketone intermediate followed by an intramolecular Friedel-Crafts acylation and dehydration to acridines.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 622-75-3. Formula: C10H8N2.