Electric Literature of 623-03-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 623-03-0, Name is 4-Chlorobenzonitrile, SMILES is ClC1=CC=C(C=C1)C#N, belongs to nitriles-buliding-blocks compound. In a article, author is Saito, Akira, introduce new discover of the category.
Direct Catalytic Asymmetric Addition of Alkylnitriles to Aldehydes with Designed Nickel-Carbene Complexes
A direct catalytic asymmetric addition of acetonitrile to aldehydes that realizes over 90 % ee is the ultimate challenge in alkylnitrile addition chemistry. Herein, we report achieving high enantioselectivity by the strategic use of a sterically demanding Ni-II pincer carbene complex, which afforded highly enantioenriched beta-hydroxynitriles. This highly atom-economical process paves the way for exploiting inexpensive acetonitrile as a promising C2 building block in a practical synthetic toolbox for asymmetric catalysis.
Electric Literature of 623-03-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 623-03-0 is helpful to your research.