Electric Literature of 2920-38-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 2920-38-9, Name is [1,1′-Biphenyl]-4-carbonitrile, SMILES is N#CC1=CC=C(C2=CC=CC=C2)C=C1, belongs to nitriles-buliding-blocks compound. In a article, author is Malik, M. Shaheer, introduce new discover of the category.
Facile Amberlyst A-21 catalyzed access of beta-hydroxynitriles via epoxide opening in water
beta-Hydroxynitriles are essential intermediates in the synthesis of diverse bioactive compounds and clinical drugs. One of the precursor reactions to these intermediates is the opening of an epoxide ring with a cyanide nucleophile. In the present study, we report a milder and safer route to beta-hydroxynitriles employing recyclable, Amberlyst A-21 resin in the ring-opening of epoxides with acetone cyanohydrin in water. A diverse range of substrates (fifteen), including aromatic epoxides, phenoxy epoxides, non-terminal, and terminal aliphatic epoxides, are investigated under the optimized conditions to afford the desired beta-hydroxynitriles in good to excellent yield. In addition to this, the recyclability of the Amberlyst A-21 resin is also successfully demonstrated. This relatively safer methodology has the potential to be explored in other organic transformations. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
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