Introduction of a new synthetic route about 2-Chloro-5-trifluoromethylbenzonitrile

According to the analysis of related databases, 328-87-0, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 328-87-0 as follows. 328-87-0

Step A: Preparation of 2-(p-methoxybenzylthio)-5-trifluoromethylbenzoic acid A solution of p-methoxybenzylmercaptan (20.0 g, 0.13 mol) and sodium methoxide (7.0 g) in N,N-dimethylformamide (55 ml) was added dropwise with stirring under a nitrogen atmosphere to a solution of 4-chloro-3-cyanobenzotrifluoride (26.7 g, 0.13 mol) in N,N-dimethylformamide (35 ml) cooled in an ice bath. After stirring for 2 hours at room temperature, the reaction mixture was poured into ice-water and extracted several times with dichloromethane. The combined organic extracts were dried (sodium sulfate) and evaporated to afford in essentially quantitative yield, 2-(4′-methoxybenzylthio)-5-trifluoromethylbenzonitrile as an oil; 60 MHZ NMR spectrum in chloroform-d was in accord with the desired structure.

According to the analysis of related databases, 328-87-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck & Co., Inc.; US4663344; (1987); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts