In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 591769-05-0 as follows. 591769-05-0
To a solution of 4-iodo-lH-pyrazole 34e (0.72 g, 3.75 mmol) in acetonitrile (10 mL) was added 3-cyclopentylacrylonitrile 34c (0.5 g, 4.12 mmol) and DBU (0.57 g, 3.75 mmol). The reaction mixture was stirred at room temperature and concentrated in vacuum. The residue obtained was dissolved in ethyl acetate washed with 1 N aqueous HC1, brine, dried and concentrated in vacuum to furnish crude as oil. The crude was purified by flash column chromatography (silica gel 24 g, eluting with 0-50percent ethyl acetate in hexane) to furnish 3- cyclopentyl-3-(4-iodo-lH-pyrazol-l-yl)propanenitrile 34f (0.845 g, 72percent) as a colorless oil;1HNMR (300 MHz, DMSO) delta 8.06 (d, J= 0.6, 1H), 7.61 (s, 1H), 4.40 (td, J= 5.2, 9.0, 1H), 3.20 – 3.04 (m, 2H), 2.39 – 2.21 (m, 1H), 1.74 (m, 1H), 1.63 – 1.36 (m, 4H), 1.33 – 1.18 (m, 2H), 1.13 – 1.02 (m, 1H).
According to the analysis of related databases, 591769-05-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda S.; KOTIAN, Pravin L.; KUMAR, V. Satish; WU, Minwan; LIN, Tsu-Hsing; WO2011/31554; (2011); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts