In an article, author is Xia, Aiyou, once mentioned the application of 53312-81-5, HPLC of Formula: C7H5FN2, Name is 5-Amino-2-fluorobenzonitrile, molecular formula is C7H5FN2, molecular weight is 136.1264, MDL number is MFCD00277872, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.
Nickel-Catalyzed Cyanation of Unactivated Alkyl Sulfonates with Zn(CN)(2)
Cyanation of unactivated primary and secondary alkyl mesylates with Zn(CN)(2) catalyzed by nickel has been developed. The reaction provides an efficient route for the synthesis of alkyl nitriles with wide substrate scope, good functional group tolerance, and compatibility with heterocyclic compounds. Mechanistic studies indicate that alkyl iodide generated in situ serves as the reactive intermediate and the gradual release of alkyl iodide is crucial for the success of the reaction.
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