15760-35-7, The chemical industry reduces the impact on the environment during synthesis 15760-35-7, name is 3-Methylenecyclobutanecarbonitrile, I believe this compound will play a more active role in future production and life.
Sodium periodate (43.0 mmol, 9.20 g) was added portion-wise to a solution of 3- methylenecyclobutanecarbonitrile (21.5 mmol, 2.00 g) and ruthenium trichloride (0.47 mmol, 98 mg) in (0880) dichloromethane : acetonitrile : water (1:1:1.5; 175 mL) . The resulting suspension was vigorously stirred (0881) overnight. The organic phase was separated then the aqueous phase was further extracted with dichloromethane (3 x 50 mL) . The combined organic extracts were dried (MgSOi) then passed through a silica plug. The solvents were removed under reduced pressure to give the title compound as a dark solid (1.58 g, 74%).
The chemical industry reduces the impact on the environment during synthesis 3-Methylenecyclobutanecarbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; SAITO, Tetsuji; HIGASHINO, Masato; KAWAHARADA, Soichi; LEWIS, Arwel; CHAMBERS, Mark Stuart; RAE, Alastair; HIRST, Kim Louise; HARTLEY, Charles David; WO2015/115673; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts