In an article, author is Ivanov, Konstantin L., once mentioned the application of 123-06-8, COA of Formula: C6H6N2O, Name is Ethoxymethylenemalononitrile, molecular formula is C6H6N2O, molecular weight is 122.1246, MDL number is MFCD00001854, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.
One-Pot Synthesis of gamma-Azidobutyronitriles and Their Intramolecular Cycloadditions
Efficient gram-scale, one-pot approaches to azidocyanobutyrates and their amidated or decarboxylated derivatives have been developed, starting from commercially available aldehydes and cyanoacetates. These techniques combine (1) Knoevenagel condensation, (2) Corey-Chaykovsky cyclopropanation and (3) nucleophilic ring opening of donor-acceptor cyclopropanes with the azide ion, as well as (4) Krapcho decarboxylation or (4 ‘) amidation. The synthetic utility of the resulting gamma-azidonitriles was demonstrated by their transformation into tetrazoles via intramolecular (3+2)-cycloaddition. A condition-dependent activation effect of the alpha-substituent was revealed in that case. Thermally activated azide-nitrile interaction did not differentiate the presence of an alpha-electron-withdrawing substituent in gamma-azidonitriles, whereas the Lewis acid mediated (SnCl(4)or TiCl4) reaction proceeded much easier for azidocyanobutyrates. This allowed us to develop an efficient procedure for converting azidocyanobutyrates into the corresponding tetrazoles.
If you are interested in 123-06-8, you can contact me at any time and look forward to more communication. COA of Formula: C6H6N2O.