These common heterocyclic compound, 25808-30-4, name is 2-(Methylamino)acetonitrile hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C3H7ClN2
Step 1: (2-Amino-ethyl)-methyl-carbamic acid tert-butyl ester To a cooled solution of methyl aminoacetonitrile hydrochloride (5.4 g, 50 mmol) in tetrahydrofuran:dimethylformamide (15 mL each) was added over 30 minutes, a solution of di-t-butyl dicarbonate (9.0 g, 50 mmol) and triethylamine (3.4 mL, 24 mmol) in tetrahydrofuran (30 mL). The reaction was stirred overnight at room temperature. The solution was concentrated and the residue taken up in ethyl acetate. The organic solution was washed with brine, dried over MgSO4, filtered and concentrated to give a brownish oil; 8.38 g, (98percent yield). MS-APCI: M+1=171. It was used without further purification. The above product was reduced in the presence of Raney nickel, in ethanol/triethylamine. The catalyst was removed and washed with ethanol. The filtrate was concentrated to give the desired product as a brownish oil; 7.13 g (84percent yield). MS-ACPI: M+1=175.
The synthetic route of 2-(Methylamino)acetonitrile hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Warner-Lambert Company; US6369034; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts