Synthetic Route of 6011-14-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6011-14-9 as follows.
4-Acetylbenzoic acid (10 g, 0.061 mol) was added to a 500 mL eggplant-shaped bottle. Add N,N-dimethylformamide (150 mL), triethylamine (18 mL, 13.5 g), HOBt (9.7 g, 0.071 mol), and stirred at room temperature for 10 min. After the solid was substantially dissolved, EDCI (13.8 g, 0.071 mol) was added and stirring was continued for 1 h. Aminoacetonitrile hydrochloride (6.16 g, 0.067 mol) was added to react at room temperature, and the reaction was followed by thin layer chromatography (TLC). After 4 h, TLC showed the reaction was completed. A large amount of solid is formed, and the reaction solution is poured into dilute hydrochloric acid (concentration: 12 to 18% by weight), stirred for 30 minutes, and the solid is precipitated, suction filtered, washed with water, and dried to obtain 4-acetyl-N-(cyanomethyl)benzoamide 11.7 g, yield 95%.
According to the analysis of related databases, 6011-14-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Fushun Daheng Chemical Co., Ltd.; Shenyang Jinjiuqi Technology Co., Ltd.; Yu Kai; Zhao Zhiwei; Qu Yuanyuan; Wang Wei; Wang Han; (25 pag.)CN108707119; (2018); A;,
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