Adding a certain compound to certain chemical reactions, such as: 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-79-7, category: nitriles-buliding-blocks
Dissolve sodium metal (0.345 g) in absolute EtOH (25 mL), add diethyloxalate (10 mL) and then add 4-methyl-3-nitrobenzonitrile (lb, m=0, 1.6 g, Aldrich) as an EtOH solution (25 mL). Stir the reaction mixture at rt for 16 hours, neutralize the reaction by addition of 5N HC1 (3 mL) and remove the EtOH under reduced pressure. Partition the residue between CH2C12 (100 mL) and H20 (50 mL). Wash the organic layer successively with H20 (50 mL) and brine (50 mL), dry (MgSO4) and concentrate to give a crude oil. Purify the oil by chromatography on SiO2 eluting with cyclohexane-EtOAc, 70-30 v/v, to afford gave after drying (40C, house vacuum), the title compound (1.5 g) as yellow crystals, mp 118 C.
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Reference:
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/23467; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts