In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-(3-Nitrophenyl)acetonitrile
To a suspension of sodium hydride (617 mg, 14.16 mmol) in dimethylformamide (16 mL) under 10C, a solution of 3-nitrophenylacetonitrile (1.15 g, 7.09 mmol) and 2-(2-bromoethoxy)tetrahydro-2H-pyran (3.24 g, 15.5 mmol) in dimethylformamide (5 mL) was added, and the mixture was stirred for 3 hours at room temperature. The reaction mixture was poured into saturated aqueous ammonium chloride and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtrated, and then the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography. To the resulting oil was added methanol (15 mL) followed by p-toluenesulfonic acid mono-hydrate (90.7 mg), and then the mixture was stirred for three and half hours at room temperature. Water was added to the reaction mixture, the mixture was concentrated in vacuo. Then, saturated aqueous ammonium chloride was added thereto, and the mixture was extracted with ethyl acetate. The combined organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtrated, and then the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatography to give 740 mg of the title compound as a yellow solid. High-performance liquid chromatography/mass spectrometry m/z 251 (M+H) Retention time: 2.09 min.
The synthetic route of 621-50-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP1679069; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts