Some common heterocyclic compound, 17420-30-3, name is 2-Amino-5-nitrobenzonitrile, molecular formula is C7H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 17420-30-3
a. 2,5-Diaminobenzonitrile To a solution of 80 grams (0.356 mole) of stannous chloride dihydrate in 200 ml. of concentrated hydrochloric acid is added in portions over the course of about 5 minutes, 16.314 grams (0.1 mole) of 5-nitroanthranilonitrile. Water cooling is used and the internal temperature rises to about 50. Stirring is continued for 4 hours and the mixture is allowed to stand overnight. The reaction mixture is cooled to 5 in an ice-bath and a cold 50% solution of sodium hydroxide added until the mixture is strongly basic. The mixture is extracted with methylene chloride. The methylene chloride extracts are washed with water and the solvent removed by distillation. There is obtained 11.51 grams (86.5%) of material melting at 85-87. Recrystallization from benzene-skellysolve B gives material melting at 86-7. The infrared spectrum is in agreement.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17420-30-3, its application will become more common.
Reference:
Patent; The Upjohn Company; US4067995; (1978); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts