Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25808-30-4, name is 2-(Methylamino)acetonitrile hydrochloride, A new synthetic method of this compound is introduced below., Computed Properties of C3H7ClN2
Example 109(4S,5R)-3-(4-(4-chlorophenoxy)phenyl)-5-(chloromethyl)-4-(3-fluorophenyl)oxazolidin-2- one; [00174] To a solution of the mesylate, prepared using the methods described in example34 (35 mg, 0.07 mmol) and triethylamine (0.125 mL, 0.9 mmol) in DMF (0.3 mL) was added methylaminoacetonitrile hydrochloride (76 mg, 0.7 mmol). The reaction was heated to 90 ¡ãC and stirred for 3 h. After cooling, and dilution with water and ethyl acetate, the organic was washed successively with 1 M HCl, brine, dried over magnesium sulfate, filtered and concentrated. HPLC purification (0-90percent acetonitrile/water) gave 16 mg (53percent) of the title compound as a colorless oil. 1H NMR (acetone-d6) delta (ppm) 7.52-7.56 (m, 2H), 7.47 (ddd, IH, J = 8.1, 8.1, 6.0
The synthetic route of 25808-30-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRM LLC; WO2008/76754; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts