Application of 403-54-3, A common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, molecular formula is C7H4FN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 3-fluorobenzonitrile (70; 20.0 g, 165 mmol) and EtOH (50 m L) and was cooled with an ice-bath. HC1 gas was bubbled through the solution unti l saturation and the reaction mixture was stirred overnight. The solid was col lected by filtration and was washed with cold ether to obtain ethyl-3-fluorobenzimidate hydrochloride as a solid (71 ; 33.5 g, 99% yield). MS (ESI) calcd for C9H,0FNO-HC1: 203.64.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.; WO2011/59839; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts