Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 3-Fluoro-4-nitrobenzonitrile
To a stirred solution of 3-fluoro-4-nitrobenzonitrile (2 g, 12.05 mmol) in CH2C12 (250 mE) under an inert atmosphere was added potassium carbonate (3.32 g, 24.09 mmol) and ethylamine (Aq. 70%, 2.17 g, 48.19 mmol) at room temperature. The reaction mixture was stirred at room temperature for 6 h. Afier consumption of starting material (by TEC), the reaction mixture was quenched with water (60 mE) and extracted with EtOAc (2×60 mE). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 3 -(ethylamino)-4-nitrobenzonitrile (1.9 g, crude) as yellow solid used in next step without thrther purification. ?H NMR (500 MHz, DMSO-d5): oe 8.22-8.10 (m, 2H), 7.58 (br s, 1H), 7.00 (br d, J=8.7 Hz, 1H), 3.48-3.38 (m, 2H), 1.21 (br t, J=6.9 Hz, 3H). EC-MS: m/z 192.1 [M+H] at 4.10 RT (98.96% purity).
According to the analysis of related databases, 218632-01-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; Hoekstra, William J.; (156 pag.)US2018/185362; (2018); A1;,
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