Adding a certain compound to certain chemical reactions, such as: 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127667-01-0, name: 2-Fluoro-5-methoxybenzonitrile
A mixture of 4-chloro-5-methyl-lH-pyrazole-3- carboxylic acid dibutylamide (1.5 g, 5.5 mmol), 2-fluoro-5-methoxybenzonitrile (1.1 g, 7.2 mmol), and cesium carbonate (1.8 g, 5.5 mmol) in dimethylformamide (5 mL) was microwaved at 130C for 30 minutes. The solvent was removed in vacuo. The crude material was eluted through a silica gel column with a 0 to 70% ethyl acetate / heptane gradient to afford the title compound (1.3 g, 59% yield) as a white solid. MS (ESI) [m/e, (M+H)+] = 403.5. NMR (400 MHz, chloroform-d) delta ppm 7.32 (d, J=8.5 Hz, 1 H), 7.18 – 7.22 (m, 1 H), 7.12 – 7.18 (m, 1 H), 3.84 (s, 3 H), 3.41 – 3.51 (m, 2 H), 3.32 – 3.41 (m, 2 H), 2.15 (s, 3 H), 1.54 – 1.66 (m, 2 H), 1.48 (qd, J=7.7, 7.5 Hz, 2 H), 1.26 – 1.40 (m, 2 H), 1.17 (ddd, J=14.9, 7.4, 7.3 Hz, 2 H), 0.89 (t, J=7.3 Hz, 3 H), 0.77 (t, J=7.3 Hz, 3 H).
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Reference:
Patent; NOVARTIS AG; VISSER, Michael Scott; YUSUFF, Naeem; WO2013/96049; (2013); A1;; ; Patent; NOVARTIS AG; FORD, Daniel; PORTER, John Robert; VISSER, Michael Scott; YUSUFF, Naeem; WO2013/96060; (2013); A1;,
Nitrile – Wikipedia,
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