Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Amino-1-cyclopropanecarbonitrile hydrochloride
The carboxylate (1 g, 1.82 mmol) and 1-amino-1-cyclopropanecarbonitrNe hydrochloride (0.2 16 g, 1.82 mmol) was suspended in DMAC (5 ml) and the stirred suspension was cooled down to 3C and then HATU (0.83 g, 2.2 mmol) was slowly added. The reaction mixture was then stirred for 15 mm and then dilsopropylethytamine (DIEA, I ml, 5.5 mrriol) was added. The mixture was stirred at 5C for another 4 hours (check by TLC 50/1 chloroform/methanol), then at -5C for 3 hours. The reaction was terminated by slow dropwiso addition of water (6 ml) at 5C and the suspension was stirred for 1 hour more. The precipitate was isolated by filtration and washed with a mixture of DMAC-H20 (10 ml – 10 ml) and dried in vacuo (180 mbar) at 45C. A white crystalline product of 0.66 g was obtained (84%, HPLC 91. 00%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 127946-77-4.
Reference:
Patent; ZENTIVA, K.S.; BABIAK, Peter; ZEZULA, Josef; (12 pag.)WO2016/95879; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts