Adding a certain compound to certain chemical reactions, such as: 17626-40-3, name is 3,4-Diaminobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17626-40-3, Safety of 3,4-Diaminobenzonitrile
EXAMPLE 1A: 2-[l-(3-PHENYL-PYRAZrN-2-YL)-PIPERIDrN-4-YL]-lH- BENZOIMIDAZOLE-5-CARBOSTEP 1. TERT-BUTYL 4-(5-CYANO-lH-BENZO[D]IMIDAZOL-2-YL)PIPERIDTNE-l- CARBOXYLATE; [00186] To the solution of piperidine- 1 , 4-dicarboxylic acid mono-tert-butyl ester ( 15 g, 65.5 mmol) in DMF (50 niL) and pyridine (50 niL) was added CDI (10.6 g, 65.5 mmol) at 45 C and the mixture was stirred for another 2h at this temperature. Then 3, 4-diamino-benzonitrile (8.7 g, 65.5 mmol) was added and the mixture was stirred at RT overnight. Solvents were removed in vacuo and the residue was dissolved in HOAc (20 mL) and heated for lh at 100 C. Then the reaction mixture was concentrated and the residue was partitioned between DCM and aqueous of a2C03. The organic layer was dried over Na2S04 and concentrated to give the crude product which was purified by column chromatography (ethyl acetate: petroleum ether=l :2) to give the compound tert-butyl 4-(5-cyano-lH-benzo[d]imidazol-2-yl)piperidine-l-carboxylate (8 g, 65%) as pale solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Diaminobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; ANDREWS, Kristin L.; FROHN, Michael J.; HARRINGTON, Paul E.; PICKRELL, Alexander J.; RZASA, Robert M.; WO2011/143129; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts