Some common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, molecular formula is C7H4FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H4FN
To a mixture of 3-fluoro- benzonitrile 43b (1.0 g, 8. 25 MMOL) and K2CO3 (2.27 mg, 16.51 MMOL) in dimethyl sulfoxide (7 mL) was added 1-benzyl piperazine (2. 14 mL, 12. 38 MMOL) and the reaction continued as described above to afford amine 199 g of 49b in 87% YIELDS. 1H-NMR (500 MHz, CDCI3) : 2. 65 (4Hs, t, J = 5.12 Hz), 3.27 (4Hs, t, J = 5.12 Hz), 3.61 (2Hs, s), 7.11-7. 15 (3Hs, m), 7.31-7. 41 (6Hs, m); ESI- MASS: 300.5 (M+23).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 403-54-3, its application will become more common.
Reference:
Patent; THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; COLORADO STATE UNIVERSITY RESEARCH FOUNDATION; WO2005/7625; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts