The important role of 17626-40-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Diaminobenzonitrile, its application will become more common.

Application of 17626-40-3,Some common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, molecular formula is C7H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: 1H-benzo[d]imidazole-5-carbonitrile3, 4-Diaminobenzonitrile (1.0 g; 7.5 mmol) was dissolved in formic acid (3 ml_) and heated at 100C for 1.5 hours. The mixture was cooled, neutralised with 10% sodium hydroxide and the resulting precipitate isolated by filtration and dried in vacuo to yield the title compound as a brown solid (890 mg; 82%). 1H NMR (DMSO-de) delta 8.50 (1 H, s), 8.19 (1 H, s), 7.79 (1 H, d, J= 8.3 Hz), 7.62 (1 H, dd, J = 8.3, 1.54 Hz). LC/MS (Method C): 144 (M+H) HPLC (Method F) Rt = 2.14 min (Purity: 99.4%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Diaminobenzonitrile, its application will become more common.

Reference:
Patent; MERCK SERONO S.A.; WO2009/80663; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts