Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 455-18-5
100 ml of tert-amyl alcohol was placed in a 250 ml three-necked flask, and 4 g of sodium was cut into sodium pellets, and then acatalytic amount of 20-40 mg of ferric chloride was added as a catalyst. Heat to 100 ~ 105 C, the reaction 2 ~ 3h. Thetemperature was lowered to 50 to 60 C, and 68.6 mmol of the compound 2-5 was added, followed by heating to 100 to 105 C.8 ml of a mixture of diisopropyl succinate compound 1 and 40 ml of tert-amyl alcohol was added to a three-necked flask througha constant pressure dropping funnel, and the mixture was 3-5 hours after 2-3 hours. Finally, react for another 4 hours, stop thereaction, pour the reaction product into a beaker, dilute with 100 ml of methanol, add acetic acid to adjust the pH to 7, filter withsuction, wash the filter cake with methanol, take the filter cake, heat and dry, then use N, The N-dimethylformamide is thermallydissolved, cooled and suction filtered, and the filter cake is washed with water and methanol, and the filter cake is taken anddried by heating to obtain the product 3-5.
According to the analysis of related databases, 455-18-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; East China University of Science and Technology; Lily Group Co., Ltd.; Wang Limin; Li Jun; Xu Jie; Wang Feng; Wang Guifeng; Wei Xiaochuan; Wang Kang; He Yulong; Lv Jinge; Yang Qingying; Zhang Yingning; Xu Meng; Tian He; Chen Lirong; (33 pag.)CN109897043; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts