Some common heterocyclic compound, 83101-12-6, name is 4-(3-Hydroxypropyl)benzonitrile, molecular formula is C10H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 83101-12-6
33C 3-(4-Cyanophenyl)propyl methanesulfonate Triethylamine (0.54 ml, 4.03 mmol) and methanesulfonyl chloride (0.30 ml, 4.03 mmol) were added to a solution of 3-(4-cyanophenyl)propan-1-ol (0.50 g, 3.10 mmol) in dry methylene chloride (15 ml), cooled at 0C and under inert atmosphere. The reaction mixture was stirred at 0C for 2 hours, after that was diluted with methylene chloride (50 ml), washed in succession with 0.05M HCl, with a NaCl saturated solution, dried and the solvent was evaporated off. 0.675 g of the title compound were obtained as a semi-solid oil (94% yield). 1H N.M.R. (300 MHz, CDCl3) delta ppm: 1.89 (m, 2H); 2.63 (t, 2H); 2.85 (s, 3H); 4.05 (t, 2H); 7.14 (d, 2H); 7.38 (d, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 83101-12-6, its application will become more common.
Reference:
Patent; LABORATORIOS MENARINI S.A.; EP775133; (2001); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts