Electric Literature of 76469-88-0,Some common heterocyclic compound, 76469-88-0, name is Methyl 4-(cyanomethyl)benzoate, molecular formula is C10H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 4-(cyanomethyl)benzoate (25g, 0.14mol) dissolved in 300mL methanol was add 160mL 1N NaOH and refluxed for3 hours. Most of the solvent was removed in vacuo. The residue was added 500mL water and acidified to pH 2-3 with concentrated HCl. The generated solid was filtered, washed with water and dried to give the title compound as white solid (21.2g, 92.2%): 1H NMR (400MHz, DMSO-d6) delta 12.89 (brs, 1H), 7.87 (d, J=8.2Hz, 2H), 7.37 (d, J=8.2Hz, 2H), 3.45 (s, 2H); MS(EI): 161[M]+.
The synthetic route of 76469-88-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Danqi; Shen, Aijun; Li, Jian; Shi, Feng; Chen, Wuyan; Ren, Jing; Liu, Hongchun; Xu, Yechun; Wang, Xin; Yang, Xinying; Sun, Yiming; Yang, Min; He, Jianhua; Wang, Yueqin; Zhang, Liping; Huang, Min; Geng, Meiyu; Xiong, Bing; Shen, Jingkang; European Journal of Medicinal Chemistry; vol. 87; (2014); p. 765 – 781;,
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