Adding a certain compound to certain chemical reactions, such as: 326-62-5, name is 2-(2-Fluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 326-62-5, category: nitriles-buliding-blocks
Step 1: 4- (2 -Fluorophenyl) tetrahydropyran-4-carbonitrile To a solution of 2-(2-fluorophenyl)acetonitrile (10.0 g,74.07 rnmol) in DMSO (300 mL) was added sodium hydride (6.8 g,170.37 mmol) at 0C portion wise. After 30 minutes, 1-chloro- 2-(2-chloroethoxy)ethane (6.2 mL, 62.9 rnmol) was added theretoin dropwise manner, and the reaction mixture was heated at 75C under nitrogen for 3 hours. The product formation was confirmed by TLC, then the reaction mixture was poured into ice cold water (3000 mL) and extracted with ethyl acetate (3x 100 mL) . The combined organic layers were washed with brine,dried over sodium sulfate and concentrated under vacuo. The residue thus obtained was purified by column chromatography using 5-8% ethyl acetate in hexane as a mobile phase to give the title compound (8.5 g, 56%)MS(EI)m/z: 206.1 (M + 1); ?H NMR (400 MHz, CDC13): 2.16-2.19(m, 2H), 2.23-2.30 (m, 2H), 3.91-3.97 (m, 2H), 4.08 (dd, J =3.6 & 11.6 Hz, 2H), 7.11-7.17 (m, 1H), 7.16-7.22 (m, 1H),7.34-7.37 (m, 1H), 7.42-7.47 (m, 1H)
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Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; DESHPANDE, Anil M.; BARAWKAR, Dinesh; PATIL, Santosh; BANKAR, Digambar; (178 pag.)WO2016/88903; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts