Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149793-69-1, name is 3-Fluoro-5-(trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Fluoro-5-(trifluoromethyl)benzonitrile
Synthesis of Intermediate (1)Molecular Weight: 189.1 Molecu lar Weight: 247.2[00495] In a 3-neck 100 mL round-bottomed flask, to a solution of propan-2-ol (1.6 mL, 1 eq.) in DMF (25 mL, 5 V) at 0 C was added 60 % NaH in mineral oil (1.5 g, 3 eq.). The reaction mixture was stirred at 0 C for 1 h and then 3-fluoro-5-(trifluoromethyl)benzonitrile (5 g, 1.25 eq.) was added and reaction was heated to 60 C for 2 h an further stirred for 12 h at room temp. Reaction completion was monitored on TLC using ethyl acetate: hexane (2:8) as mobile phase. The reaction mixture was quenched into the ice-water slurry (250 mL) and was extracted with ethyl acetate (50 mL x 3). Organic layer was washed with brine solution (50 mL x 3). The organic layer was dried using anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to provide the 5.8 g crude titled compound, yield (96 %). This crude material was directly used for next step without purification.
According to the analysis of related databases, 149793-69-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KARYOPHARM THERAPEUTICS, INC.; SHECHTER, Sharon; KAUFFMAN, Michael; SANDANYAKA, Vincent, P.; SHACHAM, Sharon; WO2011/109799; (2011); A1;,
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