13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-(3,5-Dimethoxyphenyl)acetonitrile
A mixture of 3,5-dimethoxyphenyl acetonitrile (10 g, 56.43 mmol) and methyl iodide (10.5 mL) in anhydrous DMF (280 mL) under an argon atmosphere was added dropwise (via cannula) to a solution of sodium hydride (4.06 g, 169.20 mmol) in 30 mL DMF at 0C. The mixture was warmed to room temperature and stirred for 1.5 hours. Upon completion, the reaction mixture was quenched by the addition of saturated aqueous NH4C1 and diluted with diethyl ether. The organic layer was separated and the aqueous phase was extracted with diethyl ether. The combined organic layer was washed with brine and dried (MgS04) and the solvent was evaporated under reduced pressure. The residue was purified by flash column chromatography on silica gel (10-30% ethyl acetate in hexanes) to afford 11.3 g (98% yield) of compound 6 as a viscous oil. 1H NMR (500 MHz, CDC13) delta 6.61 (d, J= 2.0 Hz, 2H, 2-H, 6-H, ArH), 6.27 (t, J= 2.0 Hz, 1H, 4-H, ArH), 3.81 (s, 6H, OMe), 1.70 (s, 6H, C(C)2C).
The synthetic route of 13388-75-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NORTHEASTERN UNIVERSITY; MAKRIYANNIS, Alexandros; D’SOUZA, Marsha, R.; BAJAJ, Shama; NIKAS, Spyridon, P.; THAKUR, Ganeshsingh, A.; WO2014/62965; (2014); A1;,
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