Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1558-82-3, name is Ethyl N-cyanoacetimidate, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks
Step F: Preparation of /V-cvaiotaio-/V-(2-(5-(2.5-dinuorophenylV3-f(.S’)-2- ntethoxypropanoyl)-2-phenyl-23-diln dro-1.3.4-thiadiaychi)l-2-yl’)ethyl)acetaniidine: To a solution of ethyl N-cyanoacctimidate (0.025 g, 0.22 mmol) and (2.USD>l-(2-(2-aminoclhyl)-5-(2,5- difluororhohenyl)-2 -phenyl- 1 ,3,4-thiadiazol-3(2//)-yl)-2-mcthoxypropan- 1 -one hydrochloride (0.018 g, 0.038 mmol) in EtOH (0.3 mL) was added diisopropylethylamine (0.033 mL, 0.19 mmol). After stirring at room temperature for 14 hours, the mixture was diluted with 10% Na^CC^ (30 mL) and extracted with dichloromcthanc. The combined organics were dried over Na^SO4, filtered and concentrated under reduced pressure. The residue was chromatographcd (3% McOH in dichloromethane) to provide the product as a mixture of diastereomers (13.0 mg, 73% yield). MS ESI (+) m’z 472 (M+l) detected; 1H NMR (400 MHz, CDCl3) 67.51 (m, 2H).7.37 (m, 6H), 7.33 (m, 4H). 7.16 (m. 4H), 6.93 (br. t, IH, J = 4.7 Hz), 6.73 (br. t, IH, J = 4.7 Hz), 4.73 (m, 2H), 4.00 (m, 2H), 3.45-3.29 (m, 9H), 3.21 (m, I H), 2.82 (m, IH), 2.75 (m, IH), 2.16 (s, 3H), 2.15 (s, 3H), 1.46 (d5 3H,J = 6.3 Hz), 1.43 (d, 3H5 J = 7.0 Hz).
The synthetic route of 1558-82-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARRAY BIOPHARMA, INC.; AHRENDT, Kateri; DELISLE, Robert, Kirk; HANS, Jeremy; LYSSIKATOS, Joseph, P.; ROBINSON, John, E.; WALLACE, Eli, M.; ZHAO, Qian; WO2008/42928; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts