Synthetic Route of 185836-35-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 185836-35-5 as follows.
A mixture of 0.93 g of lithium aluminum hydride and 30 ml ofTHF was stirred under cooling on ice. Thereafter, a mixture solution of 2.8 g of 4-benzyloxy-2-fluorobenzonitrile and 10 ml of THF was added dropwise to the reaction mixture. The obtained mixture was stirred at a room temperature for 6 hours. Thereafter, the reaction mixture solution was cooled to 0C. 0.9 ml of water, 0.9 ml of a 15% sodium hydroxide aqueous solution, and 2.7 ml of water were successively added to the reaction mixture, and the obtained mixture was stirred at a room temperature for 1 hour. Thereafter, the reaction mixture was filtrated through Celite (registered trade mark), and it was then concentrated under reduced pressure, so as to obtain 2.5 g of 4-benzyloxy-2-fluorobenzylamine.4-benzyloxy-2-fluorobenzylamine [Show Image] 1H-NMR (CDCl3) delta: 3.82 (2H, s), 5.04 (2H, s), 6.67-6.75 (2H, m), 7.18-7.24 (1H, m), 7.32-7.45 (5H, m).
According to the analysis of related databases, 185836-35-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sumitomo Chemical Company, Limited; EP2248423; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts